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Journal of Statistical Physics, Vol. 52, Nos. 1/2, 1988 Book Review: The Fluctuating Enzyme
 

Summary: Journal of Statistical Physics, Vol. 52, Nos. 1/2, 1988
Book Review: The Fluctuating Enzyme
The Fluctuating Enzyme. G. R. Welch, ed., Wiley, New York, 1986.
The idea that the role of the protein in enzymatic catalysis is not merely
geometrical but also dynamical is central in the modern study of
biophysical kinetics. According to this point of view, the protein is not just
a static structure, forming the "keyhole" that complements the shape of its
substrate: It also participates actively in the reactive event through the
dynamics of conformational change. This can occur in two ways: First,
through fluctuations around the thermal equilibrium state. In this
mechanism the reaction takes place from the wings of the thermal dis-
tribution. The second mechanism is through the relaxation of a non-
equilibrium state toward equilibrium, where the distribution function is
evolving in time.
The volume under review is a collection of nine theoretical papers
dealing with the above-mentioned questions. Although, as the title implies,
it leans toward the first mechanism, the second point of view is also
represented (Blumenfeld, Burbajev, and Davydov). Consequently, the
theoretical tools utilized are mainly those of thermodynamics and
statistical mechanics and, to a lesser extent, methods of stochastic

  

Source: Agmon, Noam - Institute of Chemistry, Hebrew University of Jerusalem

 

Collections: Chemistry