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Mol. Endocrinol. 2009 23:1702-1712 originally published online Jul 2, 2009; , doi: 10.1210/me.2009-0144 Philipp E. Scherer, Mark P. Keller, Alan D. Attie and Klaus H. Kaestner
 

Summary: Mol. Endocrinol. 2009 23:1702-1712 originally published online Jul 2, 2009; , doi: 10.1210/me.2009-0144
Philipp E. Scherer, Mark P. Keller, Alan D. Attie and Klaus H. Kaestner
Sebastian Rieck, Peter White, Jonathan Schug, Alan J. Fox, Olga Smirnova, Nan Gao, Rana K. Gupta, Zhao V. Wang,
The Transcriptional Response of the Islet to Pregnancy in Mice
Society please go to: http://mend.endojournals.org//subscriptions/
or any of the other journals published by The EndocrineMolecular EndocrinologyTo subscribe to
Copyright The Endocrine Society. All rights reserved. Print ISSN: 0021-972X. Online
The Transcriptional Response of the Islet to
Pregnancy in Mice
Sebastian Rieck, Peter White, Jonathan Schug, Alan J. Fox, Olga Smirnova,
Nan Gao, Rana K. Gupta, Zhao V. Wang, Philipp E. Scherer, Mark P. Keller,
Alan D. Attie, and Klaus H. Kaestner
Department of Genetics and Institute for Diabetes, Obesity and Metabolism (S.R., P.W., J.S., A.J.F., O.S., N.G.,
R.K.G., K.H.K.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104; Touchstone
Diabetes Center (Z.V.W., P.E.S.), University of Texas Southwestern Medical Center, Dallas, Texas; and
Department of Biochemistry (M.P.K., A.D.A.), University of Wisconsin, Madison, Wisconsin 75390
The inability of the -cell to meet the demand for insulin brought about by insulin resistance leads
to type 2 diabetes. In adults, -cell replication is one of the mechanisms thought to cause the
expansion of -cell mass. Efforts to treat diabetes require knowledge of the pathways that drive
facultative -cell proliferation in vivo. A robust physiological stimulus of -cell expansion is preg-

  

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

 

Collections: Biology and Medicine