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Summary: Probabilistic Safety and Optimal Control
for Survival Analysis of Bacillus subtilis$
Alessandro Abatea, John Lygerosb, Shankar S. Sastryc
a
Department of Aeronautics and Astronautics
Stanford University, USA
b
Automatic Control Laboratory
ETH Zurich, Switzerland
c
Department of Electrical Engineering and Computer Sciences
University of California, Berkeley, USA
Abstract
We introduce a methodological framework based on the concepts of
safety and optimality to interpret organismal strategies that are intrinsically
related to survival behaviors. We focus on the production of the antibiotic
subtilin by the bacterium Bacillus subtilis, which is one among a set of pos-
sible responses to environmental stress that are elicited by the bacterium,
and we investigate the activation strategies over the genes involved in the
process. We argue that these activation strategies can be synthesized as the
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