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Metabolic syndrome: from epidemiology to systems biology Aldons J. Lusis*,, Alan D. Attie, and Karen Reue
 

Summary: Metabolic syndrome: from epidemiology to systems biology
Aldons J. Lusis*,, Alan D. Attie§, and Karen Reue
* Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics,
David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Department of Human Genetics, University of California, Los Angeles, California 90095, USA
§ Department of Biochemistry, University of Wisconsin­Madison, Madison, Wisconsin 53706, USA
Abstract
Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and promote
the development of cardiovascular disease (CVD) and diabetes. Recent genome-wide association
studies have identified several novel susceptibility genes for MetSyn traits, and studies in rodent
models have provided important molecular insights. However, as yet, only a small fraction of the
genetic component is known. Systems-based approaches that integrate genomic, molecular and
physiological data are complementing traditional genetic and biochemical approaches to more fully
address the complexity of MetSyn.
The common forms of type 2 diabetes and cardiovascular disease (CVD) are strongly
associated with various common metabolic disturbances, including abdominal obesity, insulin
resistance, dyslipidaemias and elevated blood pressure. Since Reaven noted in 1988 that insulin
resistance could underlie much of this clustering1, a large body of work has supported the
concept that these metabolic traits exhibit causal interactions and common etiologies (BOX
1). The clustering is now known as metabolic syndrome (MetSyn), although there is

  

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

 

Collections: Biology and Medicine