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Error Rate Reduction in DNA Self-Assembly by Non-Constant Monomer Concentrations and Profiling
 

Summary: Error Rate Reduction in DNA Self-Assembly by Non-Constant Monomer
Concentrations and Profiling
B. Jang, Y-B. Kim, and F. Lombardi
Department of Electrical and Computer Engineering
Northeastern University, Boston, MA 02115
{bjang,ybk,lombardi}@ece.neu.edu
Abstract
This paper proposes a novel technique based on profil-
ing the monomers for reducing the error rate in DNA self-
assembly. This technique utilizes the average concentration
of the monomers (tiles) for a specific pattern as found by
profiling its growth. The validity of profiling and the large
difference in the concentrations of the monomers are shown
to be applicable to different tile sets. To evaluate the error
rate new Markov based models are proposed to account for
the different types of bonding (i.e. single, double and triple)
in the monomers as modification to the commonly assumed
kinetic trap model. A significant error rates reduction is
accomplished compared to a scheme with constant concen-
tration as commonly utilized under the kinetic trap model.

  

Source: Ayers, Joseph - Marine Science Center & Department of Biology, Northeastern University

 

Collections: Engineering