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Mouse Norovirus (MNV) Etiologic Agent calicivirus, positive sense ssRNA nonenveloped, resistant to
 

Summary: 1-12-2007
Mouse Norovirus (MNV)
Etiologic Agent calicivirus, positive sense ssRNA nonenveloped, resistant to
organic solvents and mild detergents, inactivated at 3 irradiation and SporKlenz
Introduction
Noroviruses are a group of genetically related and antigenically diverse
viruses that infect both humans and animals. These viruses are responsible for
the majority of acute nonbacterial gastroenteritis in humans. The disease is self-
limiting and mild with symptoms of nausea, fever, vomiting and diarrhea lasting
24-48 hours. Transmission of the virus is by ingesting material contaminated
from infected feces. These viruses infect and replicates in dendritic cells of the
gastrointestinal tract where the elaboration of cytokines leads to the disease
symptomology.
In 2003, SM Karst and CE Wobus two postdoctoral fellows in the
laboratory of HW (Skip) Virgin at Washington University in St. Louis identified
MNV-1, the first known mouse norovirus. Virgin's group showed that the mouse's
ability to fight MNV-1 infection relied heavily on the innate immune system, the
branch of the immune system that attacks invaders soon after they enter the
body (Science 299:1575-1578). MNV-1 produces a transient infection with a

  

Source: Acton, Scott - Department of Electrical and Computer Engineering, University of Virginia

 

Collections: Computer Technologies and Information Sciences