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Immunity, Vol. 11, 201212, August, 1999, Copyright 1999 by Cell Press RAG2:GFP Knockin Mice Reveal Novel Aspects
 

Summary: Immunity, Vol. 11, 201212, August, 1999, Copyright 1999 by Cell Press
RAG2:GFP Knockin Mice Reveal Novel Aspects
of RAG2 Expression in Primary
and Peripheral Lymphoid Tissues
In developing thymocytes, RAG1 and RAG2 are ex-
pressed first in the CD4 CD8 double-negative (DN)
compartment, which can be further subdivided based on
the differential expression of CD44 and CD25 (Rodewald
and Fehling, 1998). Past studies indicated that RAG ex-
Robert J. Monroe,* Katherine J. Seidl,*
Frank Gaertner,* Shuhua Han, Feng Chen,*
JoAnn Sekiguchi,* Jiyang Wang,*
Roger Ferrini,* Laurie Davidson,* Garnett Kelsoe,
and Frederick W. Alt*
pression initiates in the CD44 CD25 stage and contin-*Howard Hughes Medical Institute
ues in the ensuing CD44 CD25 stage, during whichThe Children's Hospital
TCR , , and rearrangement commences (Wilson etThe Center for Blood Research
al., 1994; Ismaili et al., 1996). Functional VDJ re-and Department of Genetics
arrangement leads to expression of a pre-TCR com-Harvard Medical School
posed of the TCR chain and the pT protein, cellularBoston, Massachusetts 02115

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine