Summary: J. Mol. Biol. (1996) 260, 588­603
The Hydration of Globular Proteins as Derived from
Volume and Compressibility Measurements: Cross
Correlating Thermodynamic and Structural Data
Tigran V. Chalikian1
, Maxim Totrov2
, Ruben Abagyan2
and
Kenneth J. Breslauer1
*
We report the first thermodynamic characterization of protein hydration1
Department of Chemistry
that does not depend on model compound data but rather is basedRutgers, The State University
exclusively on macroscopic (volumetric) and microscopic (X-ray)of New Jersey, Piscataway
NJ 08855, USA measurements on protein molecules themselves. By combining these
macroscopic and microscopic characterizations, we describe a quantitative2
The Skirball Institute of
model that allows one for the first time to predict the partial specific
Biomolecular Medicine volumes, v°, and the partial specific adiabatic compressibilities, kS°, of
New York University

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

Collections: Biology and Medicine