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DOI: 10.1002/chem.200900643 A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites
 

Summary: DOI: 10.1002/chem.200900643
A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites
and Diversify Lead Compounds
Andrew M. Sawayama,[a]
Michael M. Y. Chen,[a]
Palaniappan Kulanthaivel,[b]
Ming-Shang Kuo,[b]
Horst Hemmerle,[b]
and Frances H. Arnold*[a]
Introduction
Selective CH oxidation represents one of the great chal-
lenges for which synthetic chemists find only very substrate-
specific solutions.[14]
Breakthroughs in selective CH oxida-
tion methodology could benefit drug discovery, among other
fields, by enabling rapid and parallel analogue construction
for a specific molecular scaffold. Such improvements in effi-
ciency would greatly increase the number and variety of
compounds that could be produced, and raise the likelihood
of identifying effective therapeutic agents.

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Chemistry; Biology and Medicine