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Ann. Hum. Genet. (2002), 66, 211221 ' University College London DOI: 10.1017\S0003480002001112 Printed in the United Kingdom
 

Summary: Ann. Hum. Genet. (2002), 66, 211221 ' University College London
DOI: 10.1017\S0003480002001112 Printed in the United Kingdom
211
Mapping quantitative effects of oligogenes by allelic association
W. ZHANG", A. COLLINS", G. R. ABECASIS#, L. R. CARDON# AND N. E. MORTON"
" Human Genetics Division, Duthie Building (MP 808), Southampton General Hospital,
Tremona Road, Southampton SO16 6YD, UK
# Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK
(Received 10.10.01. Accepted 11.3.02)
SUMMARY
Regression analysis of a quantitative trait as a function of a single diallelic polymorphism has been
extended to allelic association by composite likelihood under the Malecot model for multiple
markers. We applied the method to 10 single nucleotide polymorphisms (SNPs) spanning 27 kb of
the angiotensin-I converting enzyme (ACE) gene in British families, localising a causal SNP between
G2530A and 4656(CT)3\2 in the 3h region, at a distance of 21n6p0n9 kb from the most proximal SNP
T-5491C. Neither they nor the I\D polymorphism is causal. To clarify genetic parameters we applied
combined segregation, linkage and association analysis. Stronger evidence for the 3h region was
obtained, with significant evidence of a lesser 5h effect as reported in French and Nigerian families.
However, rigorous confirmation requires that the causal SNPs be identified. Both Malecot and
parametric analysis appear to have high power by comparison with alternative methods for

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics