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Genome Biology 2007, 8:R127 commentreviewsreportsdepositedresearchrefereedresearchinteractionsinformation

Summary: Genome Biology 2007, 8:R127
Open Access2007Selaet al.Volume 8, Issue 6, Article R127Research
Comparative analysis of transposed element insertion within
human and mouse genomes reveals Alu's unique role in shaping the
human transcriptome
Noa Sela*, Britta Mersch, Nurit Gal-Mark*, Galit Lev-Maor*, Agnes Hotz-
Wagenblatt and Gil Ast*
Addresses: *Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978,
Israel. HUSAR Bioinformatics Lab, Department of Molecular Biophysics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld, D-
69120 Heidelberg, Germany.
Correspondence: Gil Ast. Email: gilast@post.tau.ac.il
2007 Sela et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transposed elements affect transcriptomes

Analysis of transposed elements in the human and mouse genomes reveals many effects on the transcriptomes, including a higher levelof exonization of Alu elements than other elements.

Background: Transposed elements (TEs) have a substantial impact on mammalian evolution and
are involved in numerous genetic diseases. We compared the impact of TEs on the human
transcriptome and the mouse transcriptome.


Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University


Collections: Biology and Medicine