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BioMed Central Page 1 of 8

Summary: BioMed Central
Page 1 of 8
(page number not for citation purposes)
BMC Developmental Biology
Open AccessResearch article
Identification of the C. elegans anaphase promoting complex
subunit Cdc26 by phenotypic profiling and functional rescue in yeast
Yan Dong1, Aliona Bogdanova2, Bianca Habermann2, Wolfgang Zachariae2
and Julie Ahringer*1
Address: 1The Gurdon Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK and 2Max
Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Email: Yan Dong - yd208@mole.bio.cam.ac.uk; Aliona Bogdanova - bogdanova@mpi-cbg.de; Bianca Habermann - habermann@mpi-cbg.de;
Wolfgang Zachariae - zachariae@mpi-cbg.de; Julie Ahringer* - jaa@mole.bio.cam.ac.uk
* Corresponding author
Background: RNA interference coupled with videorecording of C. elegans embryos is a powerful
method for identifying genes involved in cell division processes. Here we present a functional
analysis of the gene B0511.9, previously identified as a candidate cell polarity gene in an RNAi
videorecording screen of chromosome I embryonic lethal genes.
Results: Whereas weak RNAi inhibition of B0511.9 causes embryonic cell polarity defects, strong


Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge


Collections: Biology and Medicine