Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Proc. Natl. Acad. Sci. USA Vol. 93, pp. 1303613041, November 1996
 

Summary: Proc. Natl. Acad. Sci. USA
Vol. 93, pp. 1303613041, November 1996
Evolution
Evolutionary analyses of hedgehog and Hoxd-10 genes in fish
species closely related to the zebrafish
(developmental genes Sonic hedgehog functional domains homeobox paralogues)
RAFAEL ZARDOYA, EHAB ABOUHEIF, AND AXEL MEYER*
Department of Ecology and Evolution and Program in Genetics, State University of New York, Stony Brook, NY 11794-5245
Communicated by Ernst Mayr, Museum of Comparative Zoology, Cambridge, MA, August 22, 1996 (received for review April 19, 1996)
ABSTRACT The study of development has relied primar-
ily on the isolation of mutations in genes with specific func-
tions in development and on the comparison of their expres-
sion patterns in normal and mutant phenotypes. Comparative
evolutionary analyses can complement these approaches. Phy-
logenetic analyses of Sonic hedgehog (Shh) and Hoxd-10 genes
from 18 cyprinid fish species closely related to the zebrafish
provide novel insights into the functional constraints acting
on Shh. Our results confirm and extend those gained from
expression and crystalline structure analyses of this gene.
Unexpectedly, exon 1 of Shh is found to be almost invariant

  

Source: Abouheif, Ehab - Department of Biology, McGill University
Zardoya, Rafael - Biodiversidad y Biologia Evolutiva, Museo Nacional de Ciencias Naturales

 

Collections: Biology and Medicine; Environmental Sciences and Ecology