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BioMed Central Page 1 of 8
 

Summary: BioMed Central
Page 1 of 8
(page number not for citation purposes)
Molecular Pain
Open AccessShort report
Single subject pharmacological-MRI (phMRI) study: Modulation of
brain activity of psoriatic arthritis pain by cyclooxygenase-2
inhibitor
M Baliki1, J Katz2, DR Chialvo1 and AV Apkarian*1,2
Address: 1Departments of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA and 2Anesthesiology,
Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA
Email: M Baliki - m-baliki@northwestern.edu; J Katz - jkatz@nmff.org; DR Chialvo - dchialvo@ucla.edu; AV Apkarian* - a-
apkarian@northwestern.edu
* Corresponding author
Abstract
We use fMRI to examine brain activity for pain elicited by palpating joints in a single patient suffering
from psoriatic arthritis. Changes in these responses are documented when the patient ingested a
single dose of a selective cyclooxygenase-2 inhibitor (COX-2i). We show that mechanical
stimulation of the painful joints exhibited a cortical activity pattern similar to that reported for
acute pain, with activity primarily localized to the thalamus, insular, primary and secondary

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine