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BIOINFORMATICS Vol. 19 no. 5 2003, pages 553562

Vol. 19 no. 5 2003, pages 553­562
DOI: 10.1093/bioinformatics/btg057
Automatic analysis of DNA microarray images
using mathematical morphology
Jes´us Angulo and Jean Serra
Centre de Morphologie Math´ematique, Ecole des Mines de Paris, 77305
Fontainebleau, France
Received on January 14, 2002; revised on November 12, 2002; accepted on November 14, 2002
Motivation: DNA microarrays are an experimental tech-
nology which consists in arrays of thousands of discrete
DNA sequences that are printed on glass microscope
slides. Image analysis is an important aspect of microarray
experiments. The aim of this step is to reduce an image of
spots into a table with a measure of the intensity for each
spot. Efficient, accurate and automatic analysis of DNA
spot images is essential in order to use this technology in
laboratory routines.
Results: We present an automatic non-supervised set


Source: Angulo,Jesús - Centre de Morphologie Mathématique, Ecole des Mines de Paris
Cord, Aurélien - Centre de Morphologie Mathématique, Ecole des Mines de Paris


Collections: Computer Technologies and Information Sciences; Physics