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O Antigen Allows B. parapertussis to Evade B. pertussis VaccineInduced Immunity by Blocking Binding and

Summary: O Antigen Allows B. parapertussis to Evade B. pertussis
Vaccine­Induced Immunity by Blocking Binding and
Functions of Cross-Reactive Antibodies
Xuqing Zhang1
, Maria Eugenia Rodri´guez2
, Eric T. Harvill1
1 Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania, United States of America, 2 Department of Chemistry,
Centre of Applied Biotechnology (CINDEFI, CCyT La Plata), School of Science, La Plata University, La Plata, Argentina
Although the prevalence of Bordetella parapertussis varies dramatically among studies in different populations with different
vaccination regimens, there is broad agreement that whooping cough vaccines, composed only of B. pertussis antigens,
provide little if any protection against B. parapertussis. In C57BL/6 mice, a B. pertussis whole-cell vaccine (wP) provided
modest protection against B. parapertussis, which was dependent on IFN-c. The wP was much more protective against an
isogenic B. parapertussis strain lacking O-antigen than its wild-type counterpart. O-antigen inhibited binding of wP­induced
antibodies to B. parapertussis, as well as antibody-mediated opsonophagocytosis in vitro and clearance in vivo. aP­induced
antibodies also bound better in vitro to the O-antigen mutant than to wild-type B. parapertussis, but aP failed to confer
protection against wild-type or O antigen­deficient B. parapertussis in mice. Interestingly, B. parapertussis­specific
antibodies provided in addition to either wP or aP were sufficient to very rapidly reduce B. parapertussis numbers in mouse
lungs. This study identifies a mechanism by which one pathogen escapes immunity induced by vaccination against a closely


Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University


Collections: Biology and Medicine