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Evidence for an intrarenal renin-angiotensin system in the European lesser-spotted dogfish
 

Summary: Evidence for an intrarenal renin-angiotensin system in
the European lesser-spotted dogfish
A. WELLS*, W. G. ANDERSON AND N. HAZON
School of Biology, Gatty Marine Laboratory, University of St Andrews, St Andrews,
Fife, KY16 8LB, U.K.
(Received 1 February 2003, Accepted 8 August 2003)
The existence of an intrarenal renin-angiotensin system (RAS) in a perfused European
lesser-spotted dogfish Scyliorhinus canicula trunk preparation was examined by the inhibition
of angiotensin-converting enzyme by captopril. This resulted in a glomerular diuresis, an
increase in urea and chloride clearance and excretion, and an increase in transport
maxima for glucose. It is proposed that these results suggest the presence of an intrarenal
RAS. # 2003 The Fisheries Society of the British Isles
Key words: captopril; elasmobranch; intrarenal RAS; Scyliorhinus canicula.
INTRODUCTION
There is increasing support in mammals that, in addition to the systemic renin-
angiotensin system (RAS), there are local renin-angiotensin systems responsible
for the generation of angiotensin II (Ang II) within a wide range of tissues
(Henderson et al., 1993). These tissues include the kidney, heart, adrenal glands,
gonadal tissue, brain, pituitary and arterial wall (Taugner & Ganten, 1982;
Erdos & Skidgel, 1990; Hackenthal et al., 1990; Lindpainter & Ganten, 1991;

  

Source: Anderson, W. Gary - Department of Biological Sciences, University of Manitoba

 

Collections: Biology and Medicine