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Circadian Variations in Rat Liver Gene Expression: Relationships to Drug ActionsS
 

Summary: Circadian Variations in Rat Liver Gene Expression:
Relationships to Drug ActionsS
Richard R. Almon, Eric Yang, William Lai, Ioannis P. Androulakis, Debra C. DuBois,
and William J. Jusko
Departments of Biological Sciences (R.R.A., W.L., D.C.D.) and Pharmaceutical Sciences, State University of New York
at Buffalo, Buffalo, New York (R.R.A., D.C.D., W.J.J.); New York State Center of Excellence in Bioinformatics and
Life Sciences, Buffalo, New York (R.R.A., W.J.J.); and Biomedical Engineering Department, Rutgers University, Piscataway,
New Jersey (E.Y., I.P.A.)
Received April 17, 2008; accepted May 27, 2008
ABSTRACT
Chronopharmacology is an important but under-explored aspect
of therapeutics. Rhythmic variations in biological processes can
influence drug action, including pharmacodynamic responses,
due to circadian variations in the availability or functioning of drug
targets. We hypothesized that global gene expression analysis
can be useful in the identification of circadian-regulated genes
involved in drug action. Circadian variations in gene expression in
rat liver were explored using Affymetrix gene arrays. A rich time
series involving animals analyzed at 18 time points within the 24-h
cycle was generated. Of the more than 15,000 probe sets on

  

Source: Androulakis, Ioannis (Yannis) - Biomedical Engineering Department & Department of Chemical and Biochemical Engineering, Rutgers University

 

Collections: Engineering; Biology and Medicine