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Current Biology 19, 386390, March 10, 2009 2009 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2009.01.040 The GABAA Receptor RDL Acts
 

Summary: Current Biology 19, 386390, March 10, 2009 2009 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2009.01.040
Report
The GABAA Receptor RDL Acts
in Peptidergic PDF Neurons
to Promote Sleep in Drosophila
Brian Y. Chung,1 Valerie L. Kilman,1 J. Russel Keath,1,2
Jena L. Pitman,1,3 and Ravi Allada1,*
1Department of Neurobiology and Physiology
Northwestern University
Evanston, IL 60208
USA
Summary
Sleep is regulated by a circadian clock that times sleep and
wake to specific times of day and a homeostat that drives
sleep as a function of prior wakefulness [1]. To analyze the
role of the circadian clock, we have used the fruit fly
Drosophila [2]. Flies display the core behavioral features of
sleep, including relative immobility, elevated arousal thresh-
olds, and homeostatic regulation [2, 3]. We assessed sleep-
wake modulation by a core set of circadian pacemaker

  

Source: Allada, Ravi - Department of Neurobiology and Physiology, Northwestern University

 

Collections: Biology and Medicine