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RAPID COMMUNICATION From Grid Cells to Place Cells: A Mathematical Model

From Grid Cells to Place Cells: A Mathematical Model
Trygve Solstad,1
Edvard I. Moser,1
and Gaute T. Einevoll2
ABSTRACT: Anatomical connectivity and recent neurophysiological
results imply that grid cells in the medial entorhinal cortex are the prin-
cipal cortical inputs to place cells in the hippocampus. The authors pro-
pose a model in which place fields of hippocampal pyramidal cells are
formed by linear summation of appropriately weighted inputs from
entorhinal grid cells. Single confined place fields could be formed by
summing input from a modest number (1050) of grid cells with rela-
tively similar grid phases, diverse grid orientations, and a biologically
plausible range of grid spacings. When the spatial phase variation in the
grid-cell input was higher, multiple, and irregularly spaced firing fields
were formed. These observations point to a number of possible con-
straints in the organization of functional connections between grid cells
and place cells. VVC 2006 Wiley-Liss, Inc.
KEY WORDS: hippocampus; place cells; entorhinal cortex; grid cells;
spatial representation; memory


Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra


Collections: Computer Technologies and Information Sciences