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Light-Switchable Proteins DOI: 10.1002/anie.201000909

Summary: Light-Switchable Proteins
DOI: 10.1002/anie.201000909
Photocontrol of Coiled-Coil Proteins in Living Cells**
Fuzhong Zhang, Katharina A. Timm, Katja M. Arndt,* and G. Andrew Woolley*
An ability to manipulate the activity of a specific protein
inside living cells offers exciting prospects for the study of
protein function in vivo. Photocontrol, in particular, offers the
possibility of controlling protein function with very high
temporal and spatial resolution that is not easily achieved by
other methods.[1]
We aimed to develop an approach to the
photocontrol of the coiled-coil protein structural motif inside
living cells. Coiled coils in the form of basic leucine zipper
(bZIP) domains are common in transcription factors that
control gene expression in diverse settings.[2,3]
More than 50
members of this family of DNA-binding proteins are known
in humans.[4]
bZIP proteins exhibit complex spatiotemporal
patterns of activity. For example, timed expression of AP-1/


Source: Arndt, Katja - Institut für Biologie III, Albert-Ludwigs-Universität Freiburg


Collections: Biotechnology; Biology and Medicine