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Neuron, Vol. 32, 120, October 25, 2001, Copyright 2001 by Cell Press Cortical Remapping through
 

Summary: Neuron, Vol. 32, 120, October 25, 2001, Copyright 2001 by Cell Press
Cortical Remapping through
Spike Timing-Dependent Plasticity
Experimental evidence from a number of different
preparations indicates that repeated pairing of pre- and
postsynaptic action potentials can lead to long-term
Sen Song and L.F. Abbott1
Volen Center for Complex Systems and
Department of Biology
Brandeis University changes in synaptic efficacy, the sign and amplitude of
Waltham, Massachusetts 02454-9110 which depend on relative spike timing (Levy and Stew-
ard, 1983; Gustafsson et al., 1987; Debanne et al., 1994;
Magee and Johnston, 1997; Markram et al., 1997; Bell
Summary et al., 1997; Debanne et al., 1998; Bi and Poo, 1998;
Zhang et al., 1998; Egger et al. 1999; Feldman, 2000).
Long-term modification of synaptic efficacy can de- Spike timing-dependent plasticity (STDP) forces syn-
pend on the timing of pre- and postsynaptic action apses to compete with each other for control of the
potentials. In model studies, such spike timing-depen- timing of postsynaptic action potentials, and this, by
dent plasticity (STDP) introduces the desirable fea- itself, can lead to competitive Hebbian synaptic modifi-
tures of competition among synapses and regulation cation (Kempter et al., 1999; Song et al., 2000). Here,

  

Source: Abbott, Laurence - Center for Neurobiology and Behavior & Department of Physiology and Cellular Biophysics, Columbia University

 

Collections: Biology and Medicine