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BioMed Central Page 1 of 15

Summary: BioMed Central
Page 1 of 15
(page number not for citation purposes)
BMC Developmental Biology
Open AccessResearch article
Involvement of fatty acid pathways and cortical interaction of the
pronuclear complex in Caenorhabditis elegans embryonic polarity
Chad A Rappleye2, Akiko Tagawa3, Nathalie Le Bot4, Julie Ahringer4 and
Raffi V Aroian*1
Address: 1Section of Cell and Developmental Biology, Univ. of California, San Diego, La Jolla, CA 92093, U.S.A, 2present address: Dept. Molecular
Microbiology, Washington University, St. Louis, MO 63110, U.S.A, 3present address: Inst. Biochemistry, ETH Hönggerberg, CH-8093 Zürich,
Switzerland and 4Wellcome Trust/CR UK Institute, Tennis Court Road, Cambridge, CB2 1QR, UK
Email: Chad A Rappleye - rappleye@borcim.wustl.edu; Akiko Tagawa - akiko.tagawa@bc.biol.ethz.ch; Nathalie Le
Bot - n.lebot@welc.cam.ac.uk; Julie Ahringer - j.ahringer@welc.cam.ac.uk; Raffi V Aroian* - raroian@ucsd.edu
* Corresponding author Equal contributors
polarityCaenorhabditis elegansembryonic developmentNADPH-cytochrome P450 reductaseacetyl-CoA carboxylasefatty acids
Background: Cell polarity is essential for many decisions made during development. While
investigation of polarity-specific factors has yielded great insights into the polarization process, little
is known on how these polarity-specific factors link to the basic cellular mechanisms that function


Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge


Collections: Biology and Medicine