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Vol. 23 no. 13 2007, pages 16161622 BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btm150
 

Summary: Vol. 23 no. 13 2007, pages 16161622
BIOINFORMATICS ORIGINAL PAPER doi:10.1093/bioinformatics/btm150
Systems biology
A network-based method for target selection
in metabolic networks
R. Guimera` *, M. Sales-Pardo and L.A.N. Amaral
Northwestern Institute on Complex Systems (NICO) and Department of Chemical and Biological Engineering,
Northwestern University, Evanston, IL 60208, USA
Received on January 11, 2007; revised on April 5, 2007; accepted on April 13, 2007
Advance Access publication April 26, 2007
Associate Editor: Jonathan Wren
ABSTRACT
Motivation: The lack of new antimicrobials, combined with increas-
ing microbial resistance to old ones, poses a serious threat to public
health. With hundreds of genomes sequenced, systems biology
promises to help in solving this problem by uncovering new drug
targets.
Results: Here, we propose an approach that is based on the
mapping of the interactions between biochemical agents, such as
proteins and metabolites, onto complex networks. We report that

  

Source: Amaral, Luis A.N. - Department of Chemical and Biological Engineering, Northwestern University

 

Collections: Physics; Biology and Medicine