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LAdvanced Drug Delivery Reviews 37 (1999) 189211 Utilization of metabolic, transport and receptor-mediated
 

Summary: LAdvanced Drug Delivery Reviews 37 (1999) 189211
Utilization of metabolic, transport and receptor-mediated
processes to deliver agents for cancer diagnosis
*Cathy S. Cutler, Jason S. Lewis, Carolyn J. Anderson
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway, Campus Box 8225, St. Louis,
MO 63110, USA
Abstract
The use of radiopharmaceuticals for the non-invasive diagnosis of cancer has been established in diagnostic radiology over
the last few decades. In particular, with the use of sophisticated imaging modalities such as PET and SPECT and a myriad of
radioisotopes, advances have been made in the detection and treatment of cancer. This article focuses on three available
methods of tumor targeting with radiopharmaceuticals: the utilization of metabolic, transport and receptor-mediated
processes to deliver agents for cancer diagnosis. With selected reference to both clinically approved drugs and drugs
currently under development, methods of uptake are presented either in terms of flow, metabolic or receptor mediated
uptakes. A section of this article is devoted to the monitoring of cancer therapy regimes using radiopharmaceuticals. This
review also discusses some mechanistic approaches available in radiopharmaceutical chemistry to be able to effectively
diagnose and treat sufferers of cancer in the future. 1999 Elsevier Science B.V. All rights reserved.
Keywords: PET; SPECT; Radiopharmaceuticals; Cancer; Tumor; Diagnosis; Imaging
Contents
1. Introduction ............................................................................................................................................................................ 190
2. Flow and membrane transport based imaging agents .................................................................................................................. 191

  

Source: Anderson, Carolyn J. - Department of Molecular Biology and Pharmacology, Washington University in St. Louis

 

Collections: Biology and Medicine