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Deletion of the ileal basolateral bile acid transporter identifies the cellular sentinels that regulate
 

Summary: Deletion of the ileal basolateral bile acid transporter
identifies the cellular sentinels that regulate
the bile acid pool
Roger A. Davis* and Alan D. Attie
*Department of Biology, BioSciences Center, San Diego State University, San Diego, CA 92182; and Department of Biochemistry,
University of Wisconsin, Madison, WI 53706
B
ile acids are potent detergents
and are essential for efficient
digestion and absorption of di-
etary fat. Bile acids are synthe-
sized by the liver from cholesterol,
excreted into bile, and stored in the
gallbladder. After ingestion of a fat-
containing diet, the gallbladder con-
tracts, forcing bile to enter the lumen of
the proximal duodenum. Lipids in bile
acid emulsions are absorbed in the prox-
imal jejunum, whereas the majority of
bile acids are absorbed in distal ileum,

  

Source: Attie, Alan D. - Department of Biochemistry, University of Wisconsin at Madison

 

Collections: Biology and Medicine