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Summary: Department of Botany,
3359 Mississauga Road
North, University of
Toronto, Mississauga,
Ontario, Canada L5L 1C6.
e-mail: janderso@utm.
utoronto.ca
doi:10.1038/nrmicro1179
Published online 10 June 2005
EVOLUTION OF ANTIFUNGAL
DRUG RESISTANCE: MECHANISMS
AND PATHOGEN FITNESS
James B. Anderson
Abstract | Like other microorganisms, fungi exist in populations that are adaptable. Under the
selection imposed by antifungal drugs, drug-sensitive fungal pathogens frequently evolve
resistance. Although the molecular mechanisms of resistance are well-characterized, there are
few measurements of the impact of these mechanisms on pathogen fitness in different
environments. To predict resistance before a new drug is prescribed in the clinic, the full
spectrum of potential resistance mutations and the interactions among combinations of
divergent mechanisms can be determined in evolution experiments. In the search for new
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