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860 nature neuroscience volume 3 no 9 september 2000 um-dependent refilling is reported as well9. One possibility is
 

Summary: 860 nature neuroscience volume 3 no 9 september 2000
um-dependent refilling is reported as well9. One possibility is
that fast refilling is occluded in shi by accumulation of endocyt-
ic intermediates at release sites. A role for dynamin in rapid clear-
ance of these intermediates during repetitive stimulation would
complement fast, calcium-dependent refilling and contribute to
short-term maintenance of the releasable pool. Relevant findings
in adrenal chromaffin cells indicate that retrieval of vesicle mem-
branes after intense stimulation includes a calcium- and
dynamin-dependent component with fast kinetics10,11. This may
reflect a `kiss-and-run' mechanism12, in which exocytosis occurs
without collapse of the vesicle into the plasma membrane. Addi-
tional work will address the mechanism of fast synaptic fatigue
in shi in the context of the above working model.
Finally, dynamin activity is regulated by phosphorylation as
well as by interactions with its binding partners1,13, and these
mechanisms are proposed to regulate synaptic function. The pre-
sent finding that shi synapses exhibit rapid synaptic fatigue sup-
ports a role for dynamin in short-term synaptic plasticity.
ACKNOWLEDGEMENTS

  

Source: Aslin, Richard N. - Department of Brain and Cognitive Sciences, University of Rochester
Jacobs, Robert A. - Departments of Brain and Cognitive Sciences & Computer Science, University of Rochester

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences