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Adverse Effects of Template-based Warping on Spatial fMRI Analysis Bernard Ng*a

Summary: Adverse Effects of Template-based Warping on Spatial fMRI Analysis
Bernard Ng*a
, Rafeef Abugharbieha
, and Martin J. McKeownb
Biomedical Signal and Image Computing Lab, Department of Electrical and Computer Engineering
Pacific Parkinson's Research Center, Department of Medicine (Neurology)
The University of British Columbia, Vancouver, BC, Canada V6T 1Z4
Conventional voxel-based group analysis of functional magnetic resonance imaging (fMRI) data typically requires
warping each subject's brain images onto a common template to create an assumed voxel correspondence. The implicit
assumption is that aligning the anatomical structures would correspondingly align the functional regions of the subjects.
However, due to anatomical and functional inter-subject variability, mis-registration often occurs. Moreover, whole-
brain warping is likely to distort the spatial patterns of activation, which have been shown to be important markers of
task-related activation. To reduce the amount of mis-registration and distortions, warping at the brain region level has
recently been proposed. In this paper, we investigate the effects of both whole-brain and region-level warping on the
spatial patterns of activation statistics within certain regions of interests (ROIs). We have chosen to examine the bilateral
thalami and cerebellar hemispheres during a bulb-squeezing experiment, as these regions are expected to incur task-
related activation changes. Furthermore, the appreciable size difference between the thalamus and cerebellum allows for


Source: Abugharbieh, Rafeef - Department of Electrical and Computer Engineering, University of British Columbia


Collections: Biology and Medicine; Computer Technologies and Information Sciences