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Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
 

Summary: Tomosyn Inhibits Synaptic Vesicle Priming
in Caenorhabditis elegans
Elena O. Gracheva1
, Anna O. Burdina1
, Andrea M. Holgado2
, Martine Berthelot-Grosjean1
, Brian D. Ackley1
,
Gayla Hadwiger3
, Michael L. Nonet3
, Robby M. Weimer4
, Janet E. Richmond1*
1 Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois, United States of America, 2 Biology Department, Loyola University Chicago, Chicago,
Illinois, United States of America, 3 Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri, United States of America,
4 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in
the modulation of both constitutive and regulated exocytosis. To investigate how TOM-1 regulates exocytosis of
synaptic vesicles in vivo, we analyzed C. elegans tom-1 mutants. Our electrophysiological analysis indicates that
evoked postsynaptic responses at tom-1 mutant synapses are prolonged leading to a two-fold increase in total charge
transfer. The enhanced response in tom-1 mutants is not associated with any detectable changes in postsynaptic

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine