Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Copyright 2006 by the Genetics Society of America DOI: 10.1534/genetics.105.048223
 

Summary: Copyright 2006 by the Genetics Society of America
DOI: 10.1534/genetics.105.048223
Approximate Bayesian Inference Reveals Evidence for a Recent, Severe
Bottleneck in a Netherlands Population of Drosophila melanogaster
Kevin Thornton*,1
and Peter Andolfatto
*Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 and
Section of Ecology,
Behavior and Evolution, University of California, San Diego, California 92093
Manuscript received July 13, 2005
Accepted for publication October 27, 2005
ABSTRACT
Genome-wide nucleotide variation in non-African populations of Drosophila melanogaster is a subset of
variation found in East sub-Saharan African populations, suggesting a bottleneck in the history of the
former. We implement an approximate Bayesian approach to infer the timing, duration, and severity of
this putative bottleneck and ask whether this inferred model is sufficient to account for patterns of
variability observed at 115 loci scattered across the X chromosome. We estimate a recent bottleneck
0.006Ne generations ago, somewhat further in the past than suggested by biogeographical evidence. Using
various proposed statistical tests, we find that this bottleneck model is able to predict the majority of
observed features of diversity and linkage disequilibrium in the data. Thus, while precise estimates of

  

Source: Andolfatto, Peter - Department of Ecology and Evolutionary Biology, Princeton University

 

Collections: Biology and Medicine