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The Rockefeller University Press, 0021-9525/97/04/5/14 $2.00 The Journal of Cell Biology, Volume 137, Number 1, April 7, 1997 518 5
 

Summary:  The Rockefeller University Press, 0021-9525/97/04/5/14 $2.00
The Journal of Cell Biology, Volume 137, Number 1, April 7, 1997 518 5
Telomeres Cluster De Novo before the Initiation of Synapsis:
A Three-dimensional Spatial Analysis of Telomere Positions
before and during Meiotic Prophase
Hank W. Bass,* Wallace F. Marshall,
John W. Sedat,
David A. Agard,
and W. Zacheus Cande*
*Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720; and
Department
of Biochemistry and Biophysics,
Howard Hughes Medical Institute, University of California at San Francisco, San Francisco,
California 94143
Abstract. We have analyzed the progressive changes in
the spatial distribution of telomeres during meiosis us-
ing three-dimensional, high resolution fluorescence mi-
croscopy. Fixed meiotic cells of maize (Zea mays L.)
were subjected to in situ hybridization under conditions
that preserved chromosome structure, allowing identifi-

  

Source: Agard, David - Department of Biochemistry and Biophysics, University of California at San Francisco
Bass, Hank W. - Department of Biological Science, Florida State University

 

Collections: Biology and Medicine; Biotechnology