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Molecular Cell Short Article

Summary: Molecular Cell
Short Article
The Incoherent Feedforward Loop Can Provide
Fold-Change Detection in Gene Regulation
Lea Goentoro,1 Oren Shoval,2 Marc W. Kirschner,1,* and Uri Alon2,*
1Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
2Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
*Correspondence: marc@hms.harvard.edu (M.W.K.), urialon@weizmann.ac.il (U.A.)
DOI 10.1016/j.molcel.2009.11.018
Many sensory systems (e.g., vision and hearing) show
a response that is proportional to the fold-change in
the stimulus relative to the background, a feature
related to Weber's Law. Recent experiments suggest
such a fold-change detection feature in signaling
systems in cells: a response that depends on the
fold-change in the input signal, and not on its abso-
lute level. It is therefore of interest to find molecular
mechanisms of gene regulation that can provide
such fold-change detection. Here, we demonstrate


Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science


Collections: Biology and Medicine