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The [HLA-B18, F1C30, DR3] Conserved Extended Haplotype Carries a Susceptibility Gene for IgD Deficiency
 

Summary: The [HLA-B18, F1C30, DR3] Conserved Extended Haplotype
Carries a Susceptibility Gene for IgD Deficiency
BEGON~ A CALVO,1,2
LUIS CASTAN~ O,2
DEBORAH MARCUS-BAGLEY,1
DOLORES A. FICI,1
ZUHEIR AWDEH,1
and CHESTER A. ALPER1,3,4
Accepted: January 27, 2000
We showed previously that the conserved extended MHC
haplotype [HLA-B8, SC01, DR3] carries recessive susceptibil-
ity genes for IgA and IgG4 deficiency and dominant genes for
IgD and IgG3 deficiency. [HLA-B18, F1C30, DR3] has similar
class II and III regions to [HLA-B8, SC01, DR3] and is
common in the Basques. We therefore studied serum immuno-
globulin concentrations in Basque homozygotes, heterozy-
gotes, and noncarriers of (F1C30, DRB1*0301, DRB3*02,
DQA1*0501, DQB1*0201) (F1C30, DR3). As shown by oth-
ers, no subjects were deficient in IgA, IgM, or IgG subclasses.
In contrast, 29% of homozygotes and three of seven double

  

Source: Alper, Chester A. - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine