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Mathematical Modeling and Simulation of Dissolvable Aveek N. Chatterjee1
 

Summary: Mathematical Modeling and Simulation of Dissolvable
Hydrogels
Aveek N. Chatterjee1
; Qing Yu2
; J. S. Moore3
; and N. R. Aluru4
Abstract: Hydrogels have a large number of potential applications in microelectromechanical technology as sensors and actuators. In
this paper we try to understand the physics of dissolvable hydrogels and investigate the various parameters controlling the dissolution
process. Hydrogels, crosslinked via disulfide bonds, when immersed in a solution containing the disulfide cleaving agent can break
covalent cross links causing the hydrogel to dissolve and thereby indicating the presence of the cleaving agent. Such a concept can be used
to develop biochemical sensors, sacrificial structures in microfluidic systems, and other applications. The mechanism of the hydrogel
dissolution process has been studied in detail and a mathematical model has been developed. From the vanishing time of the dissolvable
hydrogel, a significant amount of qualitative and quantitative information about the solution can be obtained. A large number of factors
governing the hydrogel dissolution process were investigated by simulations and experiments.
DOI: 10.1061/ ASCE 0893-1321 2003 16:2 55
CE Database subject headings: Mathematical models; Simulation; Sensors.
Introduction
The sensitivity of hydrogels to a large number of chemical and
physical factors Kost 1990 like temperature, light, electrical
voltage, pH, ionic strength, biological, and chemical agents make

  

Source: Aluru, Narayana R. - Department of Mechanical and Industrial Engineering, University of Illinois at Urbana-Champaign

 

Collections: Engineering; Materials Science