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The In Vivo Behavior of Copper-64-Labeled Azamacrocyclic Complexes
 

Summary: The In Vivo Behavior of Copper-64-Labeled
Azamacrocyclic Complexes
Teresa M. Jones-Wilson,1
Kim A. Deal,1
Carolyn J. Anderson,1
Deborah W. McCarthy,1
Zoltan Kovacs,2
Ramunas J. Motekaitis,3
A. Dean Sherry,2
Arthur E. Martell3
and Michael J. Welch1
1
MALLINCKRODT INSTITUTE OF RADIOLOGY, WASHINGTON UNIVERSITY SCHOOL OF MEDICINE, ST. LOUIS, MO 63110, USA;
2
DEPARTMENT OF CHEMISTRY, UNIVERSITY OF TEXAS AT DALLAS, RICHARDSON, TX 75083, USA; AND 3
DEPARTMENT OF
CHEMISTRY, TEXAS A & M UNIVERSITY, COLLEGE STATION, TX 77843, USA
ABSTRACT. The use of copper radioisotopes in imaging and therapy applications has created a greater need
for bifunctional chelates (BFCs) for complexing copper radioisotopes to biomolecules. It has been demon-
strated that the charge and lipophilicity of the Cu-BFC complex has a significant effect on the in vivo behavior

  

Source: Anderson, Carolyn J. - Department of Molecular Biology and Pharmacology, Washington University in St. Louis

 

Collections: Biology and Medicine