Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
2005 Blackwell Publishing Ltd 317 Parasite Immunology, 2005, 27, 317324
 

Summary: © 2005 Blackwell Publishing Ltd 317
Parasite Immunology, 2005, 27, 317­324
Blackwell Publishing, Ltd.ORIGINAL ARTICLELitomosoides­Leishmania co-infection
Co-infected C57BL/6 mice mount appropriately polarized and
compartmentalized cytokine responses to Litomosoides sigmodontis
and Leishmania major but disease progression is altered
T. J. LAMB,* A. L. GRAHAM, L. LE GOFF & J. E. ALLEN
Institutes of Evolution, Immunology, & Infection Research, School of Biological Sciences, University of Edinburgh, UK
SUMMARY
This study examines the capacity of the mammalian host to
fully compartmentalize the response to infection with type 1
vs. type 2 inducing organisms that infect different sites in the
body. For this purpose, C57BL/6 mice were infected with the
rodent filarial nematode Litomosoides sigmodontis followed
by footpad infection with the protozoan parasite Leishmania
major. In this host, nematode infection is established in the
thoracic cavity but no microfilariae circulate in the blood-
stream. We utilized quantitative ELISPOT analysis of IL-4
and IFN- producing cells to assess cytokine bias and response
magnitude in the lymph nodes draining the sites of infection as

  

Source: Allen, Judith - School of Biological Sciences, University of Edinburgh
Graham, Andrea L. - School of Biological Sciences, University of Edinburgh

 

Collections: Biology and Medicine