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BioMed Central Page 1 of 15

Summary: BioMed Central
Page 1 of 15
(page number not for citation purposes)
Molecular Pain
Open AccessMethodology
Inflammatory and neuropathic pain animals exhibit distinct
responses to innocuous thermal and motoric challenges
Rami Jabakhanji, Jennifer M Foss, Hugo H Berra, Maria V Centeno, A
Vania Apkarian* and Dante R Chialvo
Address: Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL, 60611, USA
Email: Rami Jabakhanji - r-jabakhanji2@northwestern.edu; Jennifer M Foss - jmfoss@northwestern.edu;
Hugo H Berra - hhbonar@hotmail.com; Maria V Centeno - marivicenteno@yahoo.com.ar; A Vania Apkarian* - a-apkarian@northwestern.edu;
Dante R Chialvo - dchialvo@ucla.edu
* Corresponding author
Most current methods for assessing pain in animals are based on reflexive measures and require
constant interaction between the observer and the animal. Here we explore two new fully
automated methods to quantify the impact of pain on the overall behavior of the organism. Both
methods take advantage of the animals' natural preference for a dark environment. We used a box
divided into two compartments: dark and bright. In the motoric operant task, "AngleTrack", one


Source: Apkarian, A. Vania - Department of Physiology, Northwestern University


Collections: Biology and Medicine