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Notch is required for long-term memory in Drosophila Asaf Presente, Randy S. Boyles, Christine N. Serway, J. Steven de Belle, and Andrew J. Andres*
 

Summary: Notch is required for long-term memory in Drosophila
Asaf Presente, Randy S. Boyles, Christine N. Serway, J. Steven de Belle, and Andrew J. Andres*
Department of Biological Sciences, University of Nevada, 4505 Maryland Parkway, Las Vegas, NV 89154-4004
Communicated by Howard A. Nash, National Institutes of Health, Bethesda, MD, December 11, 2003 (received for review October 10, 2003)
A role for Notch in the elaboration of existing neural processes is
emerging that is distinct from the increasingly well understood
function of this gene in binary cell-fate decisions. Several research
groups, by using a variety of organisms, have shown that Notch is
important in the development of neural ultrastructure. Simulta-
neously, Presenilin (Psn) was identified both as a key mediator of
Notch signaling and as a site of genetic lesions that cause early-
onset Alzheimer's disease. Here we demonstrate that Notch loss of
function produces memory deficits in Drosophila melanogaster.
The effects are specific to long-term memory, which is thought to
depend on ultrastructural remodeling. We propose that Notch
plays an important role in the neural plasticity underlying consol-
idated memory.
Whereas the Notch protein plays an important role in binary
cell-fate decisions during development (1), it is also
present in the adult brain (2, 3). This finding is particularly

  

Source: Andres, Andrew - School of Life Sciences, University of Nevada at Las Vegas

 

Collections: Biology and Medicine