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Expression of the Adenovirus Receptor and Its Interaction with the Fiber Knob

Summary: Expression of the Adenovirus Receptor and Its Interaction
with the Fiber Knob
Richard P. Tomko,* Clas B. Johansson, Maxim Totrov,* Ruben Abagyan,*
Jonas FriseŽn, and Lennart Philipson*,
*Skirball Institute of Biomolecular Medicine, New York University Medical Center, 550 First Avenue, New York, New York 10016; and
Department of Cell and Molecular Biology, Karolinska Institute, Box 285, SE-17177 Stockholm, Sweden
The coxsackievirus group B (CVB) and adenovirus
(Ad) receptor (HCVADR, formerly HCAR) is a cell sur-
face protein with two immunoglobulin-like regions
(IG1 and IG2) that serves as a receptor for two struc-
turally unrelated viruses. We have established the tis-
sue distribution of the receptor in the rodent by im-
munohistochemistry and show that the receptor is
broadly expressed during embryonic development in
the central and peripheral nervous systems and in
several types of epithelial cells. The tissue distribution
is more restricted in the adult but remains high
mainly in epithelial cells. Using site-directed mutagen-
esis, based on computer modeling of the IG1 region,


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine