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Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-
 

Summary: Hydrodynamic gene delivery of baboon trypanosome
lytic factor eliminates both animal and human-
infective African trypanosomes
Russell Thomsona
, Pilar Molina-Portelaa,1
, Helen Mottb
, Mark Carringtonb
, and Jayne Rapera,2
aDepartment of Medical Parasitology, New York University Langone School of Medicine, 341, East 25th Street, New York, NY, 10010; and bDepartment of
Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
Edited by P. Borst, The Netherlands Cancer Institute, Amsterdam, The Netherlands, and approved September 2, 2009 (received for review May 21, 2009)
Several species of African trypanosomes cause fatal disease in
livestock, but most cannot infect humans due to innate trypano-
some lytic factors (TLFs). Human TLFs are pore forming high-
density lipoprotein (HDL) particles that contain apolipoprotein
L-I (apoL-I) the trypanolytic component, and haptoglobin-related
protein (Hpr), which binds free hemoglobin (Hb) in blood and
facilitates the uptake of TLF via a trypanosome haptoglobin-
hemoglobin receptor. The human-infective Trypanosoma brucei
rhodesiense escapes lysis by TLF by expression of serum resistance-

  

Source: Arnold, Jonathan - Nanoscale Science and Engineering Center & Department of Genetics, University of Georgia

 

Collections: Biotechnology