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Adrenergic-and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder
 

Summary: Adrenergic- and capsaicin-evoked nitric oxide release
from urothelium and afferent nerves in urinary bladder
LORI A. BIRDER,1 GERARD APODACA,2 WILLIAM C. DE GROAT,1 AND ANTHONY J. KANAI3
Departments of 1Pharmacology and 2Medicine, University of Pittsburgh,
Pittsburgh, Pennsylvania 15261; and 3Department of Biomedical Engineering,
Duke University, Durham, North Carolina 27508
Birder, Lori A., Gerard Apodaca, William C. de Groat,
and Anthony J. Kanai. Adrenergic- and capsaicin-evoked
nitric oxide release from urothelium and afferent nerves in
urinary bladder. Am. J. Physiol. 275 (Renal Physiol. 44):
F226F229, 1998.--Nitric oxide (NO) has been implicated in
the regulation of the lower urinary tract. However, the
source(s) of NO production in the urinary bladder (UB) has
not been determined. Accordingly, we used a porphyrinic
microsensor placed on the surface of UB strips in vitro to
directly measure endogenous NO production. The afferent
neurotoxin, capsaicin, and the mixed / -adrenergic agonist,
norepinephrine (NE), both evoked transient (13 s) NO
release (range 50 nM to 1.4 M). Adrenergic-mediated release
was not decreased following denervation of the UB but was

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine