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The neurotoxin 2#-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF
 

Summary: The neurotoxin 2#-NH2-MPTP degenerates serotonin axons
and evokes increases in hippocampal BDNF
Beth A. Luellen a
, Matthew E. Szapacs b
, Christopher K. Materese b
, Anne M. Andrews a,c,*
a
Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, United States
b
Department of Chemistry, The Pennsylvania State University, University Park, PA, United States
c
Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States
Received 12 April 2005; received in revised form 3 September 2005; accepted 5 September 2005
Abstract
1-Methyl-4-(2#-aminophenyl)-1,2,3,6-tetrahydropyridine (2#-NH2-MPTP) causes long-term depletions in cortical and hippocampal serotonin
(5-HT) and norepinephrine (NE) that are accompanied by acute elevations in glial fibrillary acidic protein (GFAP) and argyrophilia. To further
investigate the hypothesis that these changes are reflective of serotonergic and noradrenergic axonal degeneration, 2#-NH2-MPTP was admin-
istered to mice and innervation densities were determined immunocytochemically. Regional responses of the neurotrophin, brain-derived neuro-
trophic factor (BDNF), to putative damage were also assessed. Three days after 2#-NH2-MPTP, 5-HT axons exhibited a beaded, tortuous
appearance indicative of ongoing degeneration. At 21 days, numbers of serotonin axons were significantly decreased, with the greatest axonal

  

Source: Andrews, Anne M. - Huck Institutes of the Life Sciences, Pennsylvania State University

 

Collections: Biology and Medicine