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BIOINFORMATICS ORIGINAL PAPER Vol. 26 no. 4 2010, pages 470477
 

Summary: BIOINFORMATICS ORIGINAL PAPER
Vol. 26 no. 4 2010, pages 470­477
doi:10.1093/bioinformatics/btp679
Sequence analysis
A novel method for accurate one-dimensional protein structure
prediction based on fragment matching
Tuping Zhou, Nanjiang Shu and Sven Hovmöller
Division of Structural Chemistry, Stockholm University, Stockholm SE-106 91, Sweden
Received on August 17, 2009; revised on November 9, 2009; accepted on December 4, 2009
Advance Access publication December 9, 2009
Associate Editor: Limsoon Wong
ABSTRACT
Motivation: The precise prediction of one-dimensional (1D) protein
structure as represented by the protein secondary structure and 1D
string of discrete state of dihedral angles (i.e. Shape Strings) is a
prerequisite for the successful prediction of three-dimensional (3D)
structure as well as protein­protein interaction. We have developed
a novel 1D structure prediction method, called Frag1D, based on a
straightforward fragment matching algorithm and demonstrated its
success in the prediction of three sets of 1D structural alphabets, i.e.

  

Source: Aydin, Zafer - Department of Genome Sciences, University of Washington at Seattle

 

Collections: Biology and Medicine