Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
TheJournalofExperimentalMedicine The Rockefeller University Press $30.00
 

Summary: TheJournalofExperimentalMedicine
ARTICLE
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 205 No. 13 3079-3090
www.jem.org/cgi/doi/10.1084/jem.20082271
3079
Ig heavy (IgH) and light (IgL) chain variable
region exons are assembled from component
V, D, and J segments in developing B lympho-
cytes. V(D)J recombination is initiated by the
RAG1/2 endonuclease, which introduces
DNA double-strand breaks (DSBs) between
V, D, and J segments and flanking recombina-
tion signal sequences (RSs) (1). Subsequently,
cleaved coding segments are joined to form
V(D)J exons and RSs are joined to form RS
joins (2). Both coding and RS joining are per-
formed by classical nonhomologous end-join-
ing (C-NHEJ), which is a major general DSB
repair pathway in mammalian cells (3). Xrcc4

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine