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An Oscillatory Interference Model of Grid Cell Firing Neil Burgess,1,2

Summary: An Oscillatory Interference Model of Grid Cell Firing
Neil Burgess,1,2
* Caswell Barry,13
and John O'Keefe2,3
ABSTRACT: We expand upon our proposal that the oscillatory inter-
ference mechanism proposed for the phase precession effect in place
cells underlies the grid-like firing pattern of dorsomedial entorhinal grid
cells (O'Keefe and Burgess (2005) Hippocampus 15:853866). The origi-
nal one-dimensional interference model is generalized to an appropriate
two-dimensional mechanism. Specifically, dendritic subunits of layer II
medial entorhinal stellate cells provide multiple linear interference
patterns along different directions, with their product determining the
firing of the cell. Connection of appropriate speed- and direction- de-
pendent inputs onto dendritic subunits could result from an unsuper-
vised learning rule which maximizes postsynaptic firing (e.g. competi-
tive learning). These inputs cause the intrinsic oscillation of subunit
membrane potential to increase above theta frequency by an amount
proportional to the animal's speed of running in the ``preferred'' direc-
tion. The phase difference between this oscillation and a somatic input
at theta-frequency essentially integrates velocity so that the interference


Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra


Collections: Computer Technologies and Information Sciences