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Simulation of the genetic network controlling C. elegans vulval development

Summary: Simulation of the genetic network
controlling C. elegans vulval development
Rolf Lohaus1,2, Ute Platzer1, Ricardo B.R. Azevedo2, Hans-Peter Meinzer1
Division of Medical & Biological Informatics, German Cancer Research Center, Heidelberg, Germany
2 Department of Biology & Biochemistry, University of Houston, Houston, Texas, USA
The genetic state of a cell is defined by the proteins and
other gene products it contains. Changes in the genetic state
of a cell result from the interactions between genes that
constitute the genetic network. Development consists of
such cell state changes. Here we introduce a tool for
modelling and simulating the genetic network controlling the
development of the C. elegans vulva.
A network derived from the literature was modelled using the
Gene-O-Matic software. Cellular development of the vulva
was approximated using the Cell-O-Sim software. Known
inductive interactions were also incorporated into the model.
We present a simulation of the genetic state changes
observed during vulval development in wild type and mutant


Source: Azevedo, Ricardo - Department of Biology and Biochemistry, University of Houston


Collections: Biology and Medicine; Environmental Sciences and Ecology