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Summary: The role of tonic and phasic dopamine for long-term synaptic plasticity
in the prefrontal cortex: A computational model
Denis Sheynikhovich a,
, Satoru Otani b
, Angelo Arleo a
a
Laboratory of Neurobiology of Adaptive Processes, CNRS-UMR7102, UPMC-Paris 6, 9 Quai St. Bernard, F-75005 Paris, France
b
Laboratory of Psychopathology of Central Nervous System Diseases, INSERM-U952, CNRS-UMR7224, Univ. Paris 6, 9 Quai St. Bernard, F-75005 Paris, France
a r t i c l e i n f o
Keywords:
Prefrontal cortex
Long-term potentiation
Long-term depression
Dopamine
Computational model
a b s t r a c t
This work presents a computational model of dopamine (DA) influence on long-term potentiation (LTP) and
long-term depression (LTD) in the prefrontal cortex. Distinct properties of the model are a DA-concentra-
tion-dependent switch from depression to potentiation during induction of plasticity, and an inverted-U-
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