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Letters to the Editor Am. J. Hum. Genet. 75:716718, 2004

Summary: 716
Letters to the Editor
Am. J. Hum. Genet. 75:716718, 2004
No "Bias" Toward the Null Hypothesis in Most
Conventional Multipoint Nonparametric Linkage
To the Editor:
We would like to comment on the Schork and Green-
wood (2004) article dealing with the inherent "bias"
toward the null hypothesis in the context of nonpara-
metric linkage analysis. The authors point out that, in
certain situations, a loss of evidence for linkage can re-
sult from the practice of assigning expected allele-sharing
values to affected relative pairs that are uninformative
for their identity-by-descent (IBD) status. They ex-
plained this by setting up a likelihood function and stud-
ying its properties by simulation, clearly illustrating the
negative impact of using expected IBD values for un-
informative pairs. However, we would like to point out
that their likelihood does not reflect how the majority


Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan


Collections: Biology and Medicine; Mathematics