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Received 8 July 2002 Accepted 10 September 2002

Summary: Received 8 July 2002
Accepted 10 September 2002
Published online 13 December 2002
Modelling infection as a two-step process
combining gene-for-gene and matching-allele
Aneil F. Agrawal*
and Curtis M. Lively
Department of Biology, Indiana University, Bloomington, IN 47405-3700, USA
The genetic basis of infection determines the dynamics of host­parasite coevolution and associated
phenomena such as local adaptation and the evolution of sex and recombination. Here, we present parasite
resistance as a two-step process in which hosts must first detect parasites and then eradicate them; failure
at either step results in infection. The model incorporates `matching-allele' (MA) genetics for detection
and `gene-for-gene' (GFG) genetics for eradication. We found that the oscillatory dynamics were similar
to pure GFG genetics when the cost of `virulence' alleles was low, but resembled pure MA genetics when
the cost was high. The magnitude of the cost that switched the dynamics from GFG dominated to MA
dominated depended on the genetic architecture of defence (i.e. the number of GFG and MA loci).
Keywords: host­parasite coevolution; infection; genetics
Compelling evidence exists from many systems that some


Source: Agrawal, Aneil F. - Department of Ecology and Evolutionary Biology, University of Toronto


Collections: Environmental Sciences and Ecology